What You Absolutely Must Know About Detox Cleanses (But Don’t)

It could be that you’ve done it a hundred times, but there’s a few things you need to know about detox cleanses that you don’t. Learn about the three glutathione detox pathways, and how to activate them.

glutathione detox pathways

WANNA BET that even if you’re an experienced detoxer, you have no idea what you’re actually doing?

Once upon a time if you were to challenge me with such a statement, I’d bombard you with all kinds of information about herbs, cleansers, absorbers, volumnizers, processes, purges and poop.

I’ve written about 30 articles on detox cleansing. Since 1985, I’ve probably have done 100 detox cleanses in some shape or form. And yet, as I recently discovered, if you were to challenge me about what’s actually going on when “doing” a detox, in terms of what’s being “detoxed”, I’d fumble the answer.

This fumbling became clear to me when reading an article debunking detox cleansing by medical debunker Stephen Barrett, M.D. on his website, Quackwatch. It occurred to me that my understanding of detoxification could not withstand his withering cross-examination.

I knew from my own experience that by the time I reached the end of a good, thorough detox cleanse, I had more energy, whiter sclera and less fat. But what was going on inside? Or more importantly, what was going out… was I really “detoxing” anything?

From a medical perspective, “detox” refers to the liver’s function. The primary function of the liver is to filter blood. Almost 2 quarts of blood pass through the liver every minute for detoxification.

Everyone agrees that filtration of toxins is absolutely critical given that the blood from the intestines contains high levels of bacteria, bacterial endotoxins, antigen-antibody complexes, and various other toxic substances.

What’s debatable is the claim that the average liver can actually clear 99% of the bacteria and other toxins during the first pass of blood filtering through it, or during any subsequent recycling.

My confusion about this became acute when recently gathering the research to write the detox chapter of my forthcoming ebook, 12 Ageproof Biohacks. Biohack #5 is “Detox what Ages You”, and I was determined to get the science right.

I poured through many PubMed briefs of scientific studies on the subject, read what experts had to say on the matter, and watched hours of video.

These are the basics of what I learned:

  • Your various organs of elimination, particularly the liver, do a great job of cleansing and detoxing the body if every organ and system is functioning well; however…
  • For many of us in the industrialized world, pesticides, heavy metals, toxic chemicals, fungi and parasites (especially in the” third world”) are sufficiently ubiquitous that they can overwhelm our capacity to evacuate them from the body, particularly as we age; moreover…
  • Your level of toxicity is only a burden (that affects your health) if it’s too big for your detoxification system to clear out of your body, which can vary substantially from person to person; and…
  • There are three specific detoxification pathways that must work well, and work in concert with one another, in order to bind to toxins, mobilize them and evacuate them from our bodies; otherwise our health will gradually fail, and we’ll be sensitive to a whole host of chronic diseases, such as hypo/hyperthyroidism, adrenal fatigue, type-2 diabetes, metabolic syndrome, heart disease and cancer.

The rest of this article is going to explore the above four declarations, and then provide you with some resources to dig deeper into this detox topic.

Let’s begin with a look at how nature equipped us to detoxify our bodies.

 

The Standard Look At Detoxification

When someone says, “Let’s do a cleanse”, what image pops into your mind? Most likely it’s quaffing many cups of some sorta herbal tea-like brew, popping some supplements, anxiously abstaining from your daily comfort foods, and mapping out every toilet along the route of your day’s journey.

Yes, “cleansing” is often about abstinence, herbs and poo.

Gotta get all that toxic, impacted poo out of your colon because it clogs things up, makes you constipated and leeches toxins back into your bloodstream, say cleaning aficionados.

Some of that is right.

Although most proctologists and other medical doctors familiar with that geography of the body will insist that they see no impacted fecal matter clinging to your colon (they should now given those penetrating scopes and video monitoring); and despite the firm declarations that many gastroenterologist and other liver specialist make that a healthy liver is quite able to detoxify whatever xenobiotic cocktail you throw at it, only some of that is right.

I’m sorry to disappoint those of you who have either seen in your own toilet or on the Interwebs those dark, slimy, smelly, knotted, all-out disgusting poop strings, and thought them to be evidence of what the magical potions you’ve been swallowing have washed out of your colon. (Those not prone to hurling can take a look here.)

Truth be told, much of that stuff was not in you before you quaffed the cleansers, absorbers and volumizers. Sure, there’s always some poo making its way through your colon. If you eat enough fiber and vegetable matter, and drink enough water, the poo in your colon won’t be there so long that it makes you toxic.

The fetid “poop strings”, typically, are not made up of old, crusty impacted poo that the magic potions scrapped away and evacuated. They are regular, on-their-way-out poo mixed in with the potion stuff. You’re actually pooping out the stuff you recently consumed: food and potions, both.

The cleansers, absorbers and volumizers are important for proper detoxification to happen, but not for the common reasons espoused. It’s not all the toxins that originate in and hang out in your colon that you need to evacuate, but all the toxins that wind up in the colon from the rest of your body.

What’s often overlooked both by medical types and us weekend warrior detoxifiers is that, if your detox system is properly working, the poop transiting through the colon out the anus is one of the most significant absorbers and evacuators of the xenobiotics prevalent in your organs and blood.

The other major absorber and evacuator is urine.

A “cleanse” or “detox” can refer to getting rid of parasites, mold, chemicals, heavy metals and pesticides. Parasites can live nearly everywhere – in organs, the gastrointestinal tract (particularly the colon), and even the brain – and they can be tough to get rid off. Tougher yet to extract are metals and chemicals, as they get into the cells and mightily resist getting purged.

A cell’s receptor site can have a thousand-fold greater affinity for a detrimental xenobiotic than, say, a beneficial metal like zinc. What happens is that any particular toxin, like mercury, binds to the receptor site. The mercury, or any other heavy metal, will tenaciously stick to the receptor site until something comes along and chelates or binds to it, and then mobilizes it.

That “something” is glutathione, and sticking to the mercury is just the first part of what must happen to get rid of the mercury. What needs to happen next is for an enzyme to make the mercury mobile, such that it moves through the detoxification channels, typically via blood, liver, small intestine, colon and out through the anus; or via the kidney and urine.

Sounds straightforward, but this detoxification pathway gets tricky as we’ll examine further down, but first let’s establish why you should care about any of this.

 

Your Xenobiotic Load

For those of you who don’t know what “xenobiotic” means, and didn’t click the above link to find out, it’s this:

A xenobiotic is a foreign chemical substance found within an organism that is not normally naturally produced by or expected to be present within that organism. It can also cover substances that are present in much higher concentrations than are usual. (1)

That xenobiotic definition covers a lot of ground, which is why I’ve been using it. When talking about detoxing, we want to address all the toxins residing in us that are unwanted, pernicious and harmful.

The stuff in umbilical cord blood, for instance.

You might have been born long ago, in a pristine environment, and were fortunate enough to inherit a robust detoxification system, but babies born these days are not so lucky, even if genetically endowed.

Even before birth a baby needs to contend with about 287 chemicals found in umbilical cord blood, 217 of which are toxic to the brain and nervous system, these among them (2):

Mercury (Hg) – tested for 1, found 1  Pollutant from coal-fired power plants, mercury-containing products, and certain industrial processes. Accumulates in seafood. Harms brain development and function.
Polyaromatic hydrocarbons (PAHs) – tested for 18, found 9  Pollutants from burning gasoline and garbage. Linked to cancer. Accumulates in food chain.
Polybrominated dibenzodioxins and furans (PBDD/F) – tested for 12, found 7  Contaminants in brominated flame retardants. Pollutants and byproducts from plastic production and incineration. Accumulate in food chain. Toxic to developing endocrine (hormone) system
Perfluorinated chemicals (PFCs) – tested for 12, found 9  Active ingredients or breakdown products of Teflon, Scotchgard, fabric and carpet protectors, food wrap coatings. Global contaminants. Accumulate in the environment and the food chain. Linked to cancer, birth defects, and more.
Polychlorinated dibenzodioxins and furans (PCDD/F) – tested for 17, found 11  Pollutants, by-products of PVC production, industrial bleaching, and incineration. Cause cancer in humans. Persist for decades in the environment. Very toxic to developing endocrine (hormone) system.
Organochlorine pesticides (OCs) – tested for 28, found 21  DDT, chlordane and other pesticides. Largely banned in the U.S. Persist for decades in the environment. Accumulate up the food chain, to man. Cause cancer and numerous reproductive effects.
Polybrominated diphenyl ethers (PBDEs) – tested for 46, found 32  Flame retardant in furniture foam, computers, and televisions. Accumulates in the food chain and human tissues. Adversely affects brain development and the thyroid.
Polychlorinated Naphthalenes (PCNs) – tested for 70, found 50  Wood preservatives, varnishes, machine lubricating oils, waste incineration. Common PCB contaminant. Contaminate the food chain. Cause liver and kidney damage.
Polychlorinated biphenyls (PCBs) – tested for 209, found 147  Industrial insulators and lubricants. Banned in the U.S. in 1976. Persist for decades in the environment. Accumulate up the food chain, to man. Cause cancer and nervous system problems.

According to Rick Smith and Bruce Lourie, authors of Slow Death by Rubber Duck, the Environmental Working Group has also found 553 different industrial chemicals, pollutants, and pesticides in 149 Americans they tested in 27 different states.

In its Fourth National Report on Human Exposure to Environmental Chemicals, the Center for Disease Control (“CDC”) reported that the people they studied had, on average, 212 chemicals in the blood or urine, 75 of which had never before been measured in the U.S. Population.

The chemicals included (3):

  • Acrylamide – formed when foods are baked or fried at high temperatures, and as a byproduct of cigarette smoke.
  • Arsenic – found in many home-building products.
  • Environmental phenols – including bisphenol A (found in plastics, food packaging and epoxy resins) and triclosan (used as an antibacterial agent in personal care products such as toothpaste and hand soap).
  • Perchlorate – used in airplane fuel, explosives, and fireworks.
  • Perfluorinated chemicals – used to create non-stick cookware.
  • Polybrominated diphenyl ethers – used in fire retardants found in consumer products such as mattresses.
  • Volatile organic compounds (VOCs) – found in paints, air fresheners, cleaning products, cosmetics, upholstery fabrics, carpets, dry-cleaned clothing, wood preservatives, and paint strippers.

Scared yet?

Well, there’s more. Take mercury, for instance.

Contrary to the popular belief held by the newly divorced, the most toxic thing on the planet that you have an intimate relationship with is not your former spouse.

The majority of us have amalgam fillings in our mouth, eat fish from time to time and/or live close enough to various emissions emitted from various combustibles.

That means the majority of us have mercury in our body.

Over time, a lot of damage accrues if your body does not purge itself of the mercury that gets inside you (not to mention all the other heavy metals and chemical cocktails). Mercury can, in effect, epigenetically activate a genetic propensity for a chronic illness, such as hypothyroidism, cancer, diabetes and others.

Say your parents had diabetes, and you’ve inherited that genetic propensity. However, you exercise, stay slim, eat low glycemic (less sugary) carbohydrates and lots of fiber and greens. This healthy behavior prevents the physiological expression of the gene(s) for type-2 (adult-onset) diabetes. All is well, unless you become overburdened with mercury. If that happens, all bets are off. The mercury may overwhelm all your good habits and instigate the diabetes.

Ultimately, the question to answer is this:

Is your mercury load, or any other xenobiotic burden, making you ill?

 

Does Your Toxin Burden Make You Sick?

One person (A) can have teeth filled with amalgams (half of which are made with mercury), eat tuna every day, work in a coal plant and yet not exhibit any detrimental effects of his mercury load.

The person next to him shoveling coal (B) may also have those shiny silver amalgams glinting in the sunlight, and have his name etched on a stool at the sushi bar, but unlike his neighbor is slowly getting sick via an assortment of chronic diseases.

They both have the same toxic mercury load, but it’s squashing only one person, Mr. B. Mr. A has the same mercury burden but it’s not toxic to him.

Life’s unfair!

Person A might have a combination of genetics favorable for detoxification and a diet filled with nutrients that bind to and help evacuate mercury. Person B may have neither. Both get the same load, but A’s system gets it out of the body; whereas B’s does not, and so the mercury remains and does its toxic dance.

I’m focusing on mercury because the odds are that it’s in you. Most of the fillings put in people’s teeth are amalgam, commonly consisting of mercury (50%), silver (~22-32%), tin (~14%), copper (~8%), and other trace metals. (4) Most people eat at least a bit of fish (read this). And many people live in environments where mercury is in the air.

The question isn’t whether or not you have mercury in you – and an assortment of other nasty heavy metals, chemicals and other unpleasant stuff – but how much it’s negatively impacting your life.

 

The Three Detoxification Pathways

The detoxification process is an elaborate mechanism conducted chiefly by the liver to eliminate toxins, both exogenous (those that come from the environment) and endogenous (produced as a result of imbalances in our metabolism).

These three detoxification pathways are based on the glutathione system. Glutathione (GSH) is a critically important antioxidant that helps to prevent cellular damage caused by reactive oxygen species such as free radicals and peroxides.

  1. Glutathione in your cells. Your body has to manufacture most of its own glutathione (biosynthesis), so it needs adequate building blocks to make enough of it, and then the glutathione needs to link onto the mercury.
  2. Glutathione s-transferase (GST). This is an enzyme responsible linking it to the glutathione in the cell and then for prying the mercury off the cellular proteins.
  3. Transport proteins. These are a series of transport proteins (multi-drug resistant proteins, or “MRPs”) responsible for getting the conjugated mercury out of the cells and into the blood, from the blood into the liver or kidney. From the liver it will go through the bile tract into the small intestine, the colon and out the back end mixed in with poop. From the kidney it will go into the bladder and then jettison the body mixed in with urine.

Now, let’s get back to the “yes and no” equivocation about the value of the typical colon cleanse, as well as those aimed at cleaning the kidneys and anything else.

In my humble opinion, assuming you’re using high quality herbs, binders, etc. you won’t be doing yourself any harm. But unless you enhance this just described glutathione detox system, you will not be augmenting the effectiveness whatever is your own particular detox capabilities, as illustrated above with persons A and B.

The guy who has plumbed the depths of the glutathione detox system is Dr. Christopher Shade. If any of this intrigues you, watch his videos below. You’ll learn what very, very few people know about how to detox from mercury, and the information is applicable to many toxic chemicals and heavy metals as well.

 

Your Next Steps for Detoxification

If your health issues stem from toxic xenobiotic loads in your body, you may need guidance to help you go through a safe and effective detoxification program.

Before you do anything you might want to get tested or at least begin to consume the foods and supplements known to support glutathione.

Get Tested

If you only have 20 bucks to spare, you could get a quick, easy, tell you something but not much test via the HMT General Kit.

But if the guy coming up in the videos is convincing, you might want his Quicksilver Scientific Tri Speciation test.

 

 

 

Bump up Glutathione

Various foods help product glutathione, such as whey protein, garlic, onions, broccoli, kale, collards, cabbage, cauliflower, watercress, and many more.

The most direct approach is a liposomal glutathione supplement .

Bump Up Antioxidants

Vitamin C may elevate and maintain good tissue glutathione levels by increasing its rate of synthesis. In one double-blind study, the average red blood cell glutathione concentration rose nearly 50% with 500 mg/day of vitamin C. Vitamin C raises glutathione by (5)

N-acetylcysteine (NAC) replenishes intracellular levels of glutathione, helping to restore cells’ ability to fight damage from reactive oxygen species. (6)

St Mary’s thistle, also known as Milk thistle, contains silymarin, an antioxidant that may protect the liver cells from toxic damage, enhance repair of liver cells, and increase levels of glutathione in the body. Clinical trails have shown that the most effective dose of silymarin is 420mg per day. (7)

Green tea contains a group of antioxidants known as catechins, of which the most powerful is epigallocatechin gallate (EGCG). Catechins are thought to be a 200 times more powerful antioxidant than vitamin C. Along with reducing the risk of cancer and heart disease, green tea improves the efficiency of liver detoxification
reactions.

Turmeric is a plant in the ginger family with a bright yellow color, the active component of which is curcumin, a powerful antioxidant that raises the levels of glutathione in the body, and may offer protection against cancer. (8)

Limonene is a compound found in the rind of citrus fruits, particularly lemons, and is responsible for much of the smell of lemons. Limonene is a powerful antioxidant capable of blocking the harmful effects of many different free radicals.

Amalgams out

If you’ve got shinny silvery metal in your mouth, consider getting them out. Don’t just go to any dentist. No, you must go to a “biological” dentist trained in amalgam removal. If improperly done, drilling out amalgams spews bits of it down your gullet, as well as vaporizes it, which can penetrate into the brain and nervous system and make you sick.

There’s much, much more to this detox subject. If you’re interested, you’ll be able to read about such things in my forthcoming ebook, 12 Ageproof Biohacks, which I hope to finish before hell freezes over.

Get on the list here:  Biohack List

 

P.S.  Go check out the rest of the detox articles on this site right here.

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Joe Garma
 

I help people live with more vitality and strength. I'm a big believer in sustainability, and am a bit nutty about optimizing my diet, supplements, hormones and exercise. To get exclusive Updates, tips and be on your way to a stronger, more youthful body, join my weekly Newsletter. You can also find me on LinkedIn, Twitter and Instagram.

Click Here to Leave a Comment Below 9 comments
Michele - March 8, 2015

Great article! Looking forward to your book.

Reply
Joe Garma - March 8, 2015

Thanks Michele… appreciate the compliment, and I too look forward to the book! 😉 (It’s been very tough to write.)

Reply
Angele - September 27, 2015

Back in 1999 I had my (any) dentist replace all the silver fillings. The beginning of the new millennium was a time of unexplainable poor health. Very poor health hence a time of misery for me. Never had pneumonia previosly yet I got pneumonia two times in one year plus chronic fatigue, depression and countless other ailments.

Took me almost a decade to get back to feeling okay. My last blood work and fasting exam has me perfectly healthy now but I was in the hospital for five days when the first illness struck back then. Reminds me of the TV show about the doctor called House. I experienced the cat scan and many new exams that should never have happened had I read this article back then.

Thank you Joe for finally clearing up the mystery because prior to the 1999 removal of the silver fillings I considered myself to be very healthy.

Reply
Joe Garma - September 27, 2015

Angele, if the dentist who removed your amalgams was not trained in the technique (the “Huggins Protocol”), then you might have gotten a surge of mercury-tainted material in your body during the process, thus the long stretch of poor health as your body attempted to excrete it.

Not only does a person need the right dentist to remove amalgams (often refereed to as “Biological Dentists”), but they also need to go on a mercury detox protocol using supplements (such as glutathione) that will help exit the mercury.

Glad you’re better!

Reply
Angele - September 27, 2015

Thanks for clearing things up.

One good thing came out of it all. I now do not take health for granted. My family doctor, from the dark days, told me a few times it was in my head when illnesses lingered. Have replaced her with a practitioner, who is kind enough to give me a Metformin prescription for the off label anti-aging properties. I do not have diabetes and am not pre diabetic. Have to say the metformin makes me feel more alive. Ive been taking it since Labour Day this month. Any comments on the Metformin, could it be placebo?

Reply
Angele - September 27, 2015

Thanks Joe

Am reading what you have to say about Metformin here…https://www.garmaonhealth.com/control-your-blood-sugar/

Reply
Joe Garma - September 27, 2015

Dr. Ward Dean is a long-time anti-aging doctor who likes metformin. Read this: http://warddeanmd.com/dr-deans-recommended-antiaging-medicine/ And keep tabs on side-effects: http://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral/metformin-oral/details#side-effects

Reply
kare anderson - February 26, 2017

You are certainly thorough in writing about detox yet I am a bit in overwhelm at the end + will buy some of the supplements recommended and am gratified to see I eat many of those listed in Bump Up Antioxidants + I look forward to reading your upcoming book

Reply
Joe Garma - February 26, 2017

Yes, Kare, and I look forward to finishing it!

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