ProHealth’s Rich Carson calls it, “almost a miracle drug”. I call SAM-e the “triple threat”, for it threatens to vanquish depression, arthritis and liver dysfunction.  SAM-e is a powerful, natural supplement that can be superior to antidepressants and as effective as NSAIDs for osteoarthritis, without the negative side effects. Watch the video.  Learn how to use it and where to get it below.

IN THIS post, Rich Carson and Karen Lee Richards team up to laud the multiple powers of the natural supplement, SAM-e.  If you’d like to improve the health of your joints or liver, or could use a healthy mood enhancer, read Ms. Richards’ summary of the SAM-e research, and watch Rich Carson’s interview.

Rich Carson is my long-time friend, an expert on supplements and the founder of ProHealth, Inc. Karen Lee Richards is Lead Expert specializing in Fibromyalgia and ME/CFS, for HealthCentral’s ChronicPainConnection.

You couldn’t find two better people to tell you about how SAM-e helps promote a natural improvement in the symptoms of osteoarthritis, depression and liver disease.

I call SAM-e the triple threat supplement – relief from joint pain, blue moods and liver ills.  I take 400 milligrams every morning.

Here, Rich Carson introduces you to the substantial benefits of SAM-e:

OK, now that you’ve absorbed the basics, I’d like to summarize some of Karen Lee Richard’s research on SAM-e from her article, SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood. (Thanks to ProHealth for reprint permission.)

Let’s start out by quoting Ms. Richard’s lead paragraph to set the stage:

“Clinical trials have shown SAM-e to be comparable to prescription antidepressants for depression and as effective as NSAIDs for osteoarthritis. But, as SAM-e supports the body’s natural mood and inflammation modulating functions, it doesn’t have all the negative side effects associated with those drugs.”

[I’d argue that SAM-e might be superior to prescription antidepressant, cause they’re ineffective for many users with mild to moderate depression, as Dr. Andrew Weil discusses in this post, Dr. Weil’s Four Alternatives to Antidepressant Drugs.]

Unlike most supplements, SAM-e (S-adenosyl methionine) is not an herb or a vitamin, but rather a molecule naturally produced in all living cells. It is sold as a dietary supplement in the U.S, although it is powerful enough to be designated as a drug, as it is in at least 14 countries.

Thousands of research studies have been conducted all around the world on SAM-e, investigating its supportive effect in those with many different diseases and conditions, including depression, osteoarthritis, chronic liver disease, fibromyalgia, and Alzheimer’s disease.

Let’s delve a bit into how SAM-e can help with each of these diseases and conditions.

SAM-e and Depression

Significant Improvement Seen in Major Depression with SAM-e

Based on my readings and simple, non-scientific self-experimentation, I’ve argued in Dr. Weil’s Four Alternatives to Antidepressant Drugs and A Little Depressed? 10 Actions That Help Me that antidepressant drugs are NOT the way to go for treating mild to moderate depression. (Get your doctor to weigh in here, cause I’m not one for sure!)

Consider three points that Ms. Richards presents about SAM-e’s value to helping with depression (and then note my comment right after):

•  SAM-e has been studied extensively over three decades as a possible option for those with depression, perhaps because 29% to 46% of patients with major depressive disorder have no response or only a partial response to pharmaceutical antidepressants. At this point, there’s an impressive body of literature suggesting the mood-supporting efficacy of SAM-e.

•  In an open trial, 20 outpatients with major depression were given SAM-e, beginning with 400 mg/day and gradually increasing to 1600 mg/day by day 12.  Nine of the participants had a prior history of not responding to traditional antidepressant treatment. All 20 patients showed significant improvement with SAM-e, including seven of the non-treatment resistant and two of the treatment-resistant patients who experienced a full antidepressant response.

•  A double-blind randomized trial compared the efficacy of supplemental SAM-e with the antidepressant desipramine in 26 patients with major depression. At the end of four weeks, 62% of those given SAM-e had significant improvement compared to 50% of those taking desipramine.

OK, here’s my note about the above three bullet points: The studies cited indicate what they indicate, but, frankly, I’d feel uncomfortable to suggest that people experiencing anything but mild to moderate depression trash their doctor prescribed antidepressants in favor of SAM-e.  If you’ve been diagnosed as having strong/severe depression or other psychiatric issues, DO NOT trash your prescribed drugs in favor of SAM-e; rather, take counsel with your doctor!

SAM-e and Joints

Impressive Results in Osteoarthritis Patients Using SAM-e

In her article, Ms. Richards continues with her review of SAM-e, citing how it can benefit those suffering from Osteoarthritis.

She reports that an estimated 27 million people have osteoarthritis, making it the most common form of arthritis.

(Below, I reprint Ms. Richards words; the bold words are my emphasis…)

The pharmaceutical treatment for osteoarthritis is non-steroidal anti-inflammatory drugs (NSAIDs) – either over-the-counter medications like aspirin, ibuprofen and naproxen, or prescription medications like Celebrex, Relafen, Daypro, etc.

While NSAIDs can be effective pain relievers, their regular use can result in some devastating side effects such as ulcers and other gastrointestinal problems, increased blood pressure and kidney damage.

Notwithstanding the side effects, in the long run NSAIDs may actually worsen joint problems because they slow the production of collagen and proteoglycans, which help to make cartilage an effective shock absorber.

By contrast, SAM-e seems to support an anti-inflammatory response equivalent to the effect of NSAIDs, but without the toxic side effects. SAM-e does not harm the digestive tract, nor does it contribute to the breakdown of cartilage. Instead, one study shows it may actually help the body restore damaged cartilage.

•  A meta-analysis of 11 clinical trials involving 1,142 patients was done looking at SAM-e for support of osteoarthritis symptom relief. The study authors concluded, “SAM-e appears to be as effective as NSAIDs in reducing pain and improving functional limitation in patients with OA without the adverse effects often associated with NSAID therapies.”

•  A randomized double-blind cross-over study of 56 patients diagnosed with osteoarthritis of the knee compared SAM-e (1200 mg) with the prescription drug celecoxib (Celebrex 200 mg). The results showed no significant difference between the two – both patient cohorts demonstrated significant improvements in pain and joint function – leading the researchers to conclude that SAM-e was as effective as celecoxib in managing the symptoms of knee osteoarthritis.

•  In a German study, 21 patients with finger osteoarthritis were given SAM-e for three months. MRI scans done on their hands both before and after the treatment period revealed significant structural improvement in the cartilage.

SAM-e and the Liver

SAM-e Supports the Prevention and Improvement of Liver Disease

I’m still amazed when I think about how unique is the liver. The liver is unique because it is the only internal human organ capable of regenerating itself. Did you know that a liver reduced to 25% of its normal size could regenerate into a whole liver again?

SAM-e plays a leading role in that regeneration.

SAM-e is thought to be beneficial for those with liver disease by acting as a precursor of antioxidant glutathione; repairing the mitochondrial glutathione transport system; inhibiting the toxic effects of proinflammatory cytokines; and increasing DNA methylation.

There are nearly a thousand published studies documenting SAM-e’s ability to support prevention and improvement in liver disease.  Back to Ms. Richards:

•  In a study of hepatic glutathione levels in patients with liver disease, participants were divided into four groups. Nine patients with alcoholic liver disease were given SAM-e; seven patients with non-alcoholic liver disease were given SAM-e; 8 patients with alcoholic liver disease were given a placebo; and 15 normal subjects served as a control group. Prior to beginning treatment, all patients had very low hepatic glutathione levels compared to controls. Following treatment, patients receiving the SAM-e had a significant increase in their hepatic glutathione levels compared with both the placebo-treated group and controls.

•  When SAM-e was given to 62 patients with alcoholic cirrhosis in a clinical trial, they were significantly less likely to die or require a liver transplant within the next two years, compared with 61 patients who had received a placebo.

SAM-e and Fibromyaliga

SAM-e Is Promising for Fibromyalgia Patients

Although SAM-e has not been studied yet as much for support of fibromyalgia patients as for those with some other illnesses, the results thus far are encouraging. In one double-blind study of 44 patients with primary fibromyalgia, improvements were seen in the areas of clinical disease activity, pain, fatigue, morning stiffness and mood.

SAM-e and Alzheimer’s Disease

SAM-e May Help Prevent or Delay Alzheimer’s Disease

Since extremely low levels of SAM-e were found in the cerebrodpinal fluid and brain regions of Alzheimer’s patients in a 1996 study, researchers are examining the potential benefits of supplemental SAM-e in Alzheimer’s.(11)  A recent study stated, “…our findings suggest that dietary supplementation with SAM… holds promise as a therapeutic approach to prevent or delay AD. A preliminary study indicates that SAM can provide some cognitive improvement in AD patients.”

How to Use SAM-e

Facts About SAM-e You Need to Know

Dosage: Recommended therapeutic doses usually range between 400 – 1600 mg a day, although some individuals may require higher doses. Studies suggest that 400 mg per day may be adequate for osteoarthritis patients, while up to 1600 mg a day is often needed for mood support. The usual dose for those with liver disorders has been 1600 mg a day. (As with any addition to your health support regimen, supplementation with SAM-e should be considered only with the approval of your professional healthcare team.)

How to Take SAM-e: SAM-e works best when taken on an empty stomach. Because it is absorbed mainly in the intestine, enteric-coated tablets that allow it to pass through the stomach intact are preferable. Leave tablets in their foil or foil blister packs until you are ready to take them in order to maintain their stability.

Adverse Effects: There seem to be few adverse effects with SAM-e, even at high doses. Occasionally mild gastrointestinal distress has been reported. Since SAM-e can sometimes lead to insomnia, it is usually best to take it early in the morning. Because it plays a role in mood support, SAM-e may trigger manic episodes in people with bipolar disorder.

Contraindications: While there are no confirmed drug interactions with SAM-e, individuals using prescribed medications such as antidepressants, including serotonin re-uptake Inhibitors and MAO inhibitors, should consult a physician before using. Individuals with Parkinson’s disease, bipolar disorder or manic depression should not take SAM-e.

Some Final Words About SAM-e

The Data

The assertions reproduced here are footnoted by Karen Lee Richards’ article her from which they’re extracted.  If you’re interested in the studies she cites, please go to her article, SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood.

You’ll discover that more than three decades of solid research support the use of SAM-e to help promote natural improvement in symptoms of osteoarthritis, depression and liver disease.

Where to Buy SAM-e

I suggest you get it at ProHealth, where I get mine.  SAM-e has been one of the cornerstone supplements offered by ProHealth for many years because it’s useful for so many chronic aliments.

This is how I present it in the Products section of this site:

ProSAMe This supplement is a wunderkind – it helps to stabilize moods, support healthy joints AND liver function. It’s an important part of my arsenal, but I refrain from taking it all the time, as I like to check in, unadulterated, to see how my natural emotional well being is doing.

Note: I have an affiliate marketing arrangement with ProHealth, which means if you buy SAM-e from the above link, I will get a commission from them.  This does not at all affect the price you pay.  If you don’t wish for me to get a commission, simply go to ProHealth, search for SAM-e and buy it there.

Well, lots to digest with this post.  If you have comments or questions, please submit them in the Comments section below.

Related posts:

1. Do Depression Drugs Work?
2. Get Relief from Depression with Rumi
3. A Little Depressed? 10 Actions That Help Me

Since in America 2/3rds of us are overweight, knowing about the ultimate risk of belly fat is both urgent and important. The facts recently uncovered are shocking!  Learn about the damage that excess fat can do, and how to minimize the risks.

WITH THANKSGIVING one day away, this subject may be viewed as heresy because it deals with diet, but I just learned a few things from yesterday’s Dr. Oz show and if I don’t write about it now, it may elude me later.  Let me add that it’s important for you to know this.

As Dr. Oz reports, the science is clear, and what it says is disturbing given that about 2/3rds of all Americans are overweight.  What we know now is that…

Fat can cause cancer!

This eye-popping assertion was the subject of yesterday’s Dr. Oz show, where he and Dr. Kathleen Wolin, an expert on the matter, delved into how fat causes cancer, what types of cancer fat can cause and what can be done to mitigate the risk.

And the risk is substantial.  To underscore this, I’ll ask you a question.  What do you think has the greatest potential to cause cancer, smoking cigarettes or being overweight?

The answer: Both smoking cigarettes and being overweight carry the same risk of creating cancer – a 30% chance each.

What the studies now demonstrate is that belly fat not only increases the risk of diabetes and heart disease, the so called “diabesity”, but of four types of cancer as well.  The four cancers are: Pancreatic Cancer, Colon Cancer, Kidney Cancer and Endometrial Cancer.

If you’re overweight by more than ten pounds, and certainly if you’re obese, you now have a very big reason to take the bull by the horns and lose weight.  If you’ve tried before and weren’t successful, this is the time to seek help, particularly if anyone in your family had any of the four fat-influenced cancers, diabetes or heart disease.

A Special Kind of Fat

What is under scrutiny here is not all fat irrespective of where it is on your body, but belly fat.  Not all fat has the same damage potential.  The fat on your thighs is not as harmful as that hanging around your belly.

Belly fat is called the “omentum”. Omentum is defined by About.com to be:

“… a large fatty structure which essentially hangs off the middle of your colon and drapes over the intestines inside the abdomen to be It is a hormone producer that disrupts normative chemicals in your body. These hormonal chemicals can feed cancer cells and resist the immune system’s response to them.”  (Source here.)

Here’s what it looks like:  

The 4 Cancers that Fat Can Cause

The one common characteristic of the four cancers that fat can cause is that they are all in organs located in proximity to the belly fat, especially when the fat covers a lot of ground – left, right, up, down, out and round.

1. Pancreatic Cancer.  As you may know, the pancreas is deep in the abdomen below the stomach and liver, which makes it close to the belly.  The pancreas helps regulate how the body processes sugar by producing insulin.  If impaired, the pancreas may have difficulty producing insulin, which is the major cause of diabetes.  What’s now known is that a pancreas that can’t regulate sugar due to excess belly fat leaves it vulnerable to cancer.

Reduce this risk by eating foods rich in folates, such as eggs, asparagus, oranges and green leafy vegetables.

2. Colon Cancer.  The omentum lies over the colon and gets entwined within it.  The pernicious effect it has on the colon is through increasing inflammation and reducing immune function.

Reduce this risk by taking two “baby” aspirin daily in warm water so that it’s quickly dissolved. Another tip is to take a curcumin supplement, as this herb is very useful in reducing inflammation.  To increase immune function, consider the supplements listed in Power Up Your Immune System and Antioxidants Kill Free Radicals.

3. Kidney Cancer. Belly fat is a major producer of the hormone “leptin” which can fuel cancer growth as it helps the blood vessels that feed the cancer cells in the kidney.

Reduce this risk by lowering your salt consumption, increasing potassium, and eating foods such as bananas, apricots and broccoli (all high in potassium).

4. Endometrial (Uterine) Cancer.  The omenum fat excretes estrogen and bathes the uterine in it constantly, hyper-stimulating it.  This can result in cancer.

Reduce this risk by drinking a cup of coffee without sugar and cream.  The thought is that coffee helps stimulate metabolism which has the effect of reducing estrogen, although the science is not clear on this.  Personally, I rather drink green tea for the metabolic stimulating effect.  I do this and take the Green Tea Mega supplement.

A 35+ Inch Waist is Dangerous

How do you know if you’re carrying too much belly fat?  Well, I guess it’s a good sign if you’re unsure, for if it’s not completely obvious, you may not be in the danger zone.  But just to make sure, here’s how to measure your waist:

Take your tape measure and bring it across your belly button and hips.  You can suck your belly in. Look down at the tape and gasp!  If the measurement is more than 35 inches for a woman, or 40 inches for a man, you need to take some weight loss measures.

One important thing to point out here, particularly to those of you who don’t consider yourself overweight, and that is maybe tomorrow you will be. In fact, odds are that as the years unfold, so will your belly.

The reason is that the average American adds a couple of pounds each year as we get older. The weight sneaks up on us, and as it does, so do the cancer risks described here. Obviously, it’s really important that you pay attention and not be lax about what might initially seem to be the gaining of a few pounds.

[Here are Dr. Oz’s five life saving numbers you should know.]

Tips and Tricks for Weight Loss

It’s beyond the scope of this post to deeply dig into a weight loss system, and surely there’s enough information on the Web about that.  I can suggest a few things, however, to get you on your way.

1. Get educated on the subject.  On this blog, you can read Dr Oz and the 14-Day Reboot Diet Plan, Diet 101 and The Basics – My Approach to Health.

2. Choose a few things that you’re willing to do to lose weight and add one each week or so.  For instance, one week you can reduce your red meat consumption to two servings and increase your green leafy vegetables to five servings.  One week, walk x blocks, week two 2x blocks.

3. Recruit a buddy.  This person will keep you on your plan and vice versa.

4. Establish new, healthy habits that you do at specific time each day.  For instance:

- Upon waking, first thing, drink as much purified water as you can.

- Then consume 20 to 30 grams of protein, either a whey, hemp, pea or rice protein supplement, and/or eggs and beans… in any event, ALWAYS eat something balanced and good for breakfast (see #1).

- Throughout the day, drink water with apple cider vinegar in it, about one teaspoon per eight ounces, or if you can’t stand the taste that way, first put the vinegar in your mouth and then chase it with water.  Vinegar is a good fat emulsifier.

- When eating high glycemic foods (white food – wheat, rice and such, sugary foods, packaged foods) add some vinegar or cinnamon to slow down the blood glucose reaction.

- Eat fiber-rich foods and have a back-up plan in case your day is taking you away from such foods.  A back-up plan would be to have some flax seed powder (grind fax seeds in your coffee grinder, or buy them already grounded) or psyllium husk powder and scoop  a tablespoon into a shaker jar filled with water, lemon water, or water with a touch of apple juice.

Drink it down fast before it congeals.

Mobility – Use It or Lose It!

My final statement here goes without saying but I’ll say it:

Each of the risk reducing behaviors cited above for the four different cancers influenced by fat can be made dramatically more effective with exercise.

There’s no getting around the fact that our bodies are made to move.  For most of us in the modern world, they only move from a building to a car to the dinner table.  Insufficient!  If you don’t know how to exercise, find out.  As I mentioned above, recruit a buddy and make it your business to find out how to exercise.

And make sure part of your exercise program includes stuff that makes you breathe heavily (aerobic/anaerobic) , stuff that works your muscles thoroughly (resistance training) and stuff that stretches you (like yoga).  Here’s a five-minute session to get you started.

OK… it’s Thanksgiving, go be thankful, eat heartily but consciously, and resolve to do some things differently.  Please share this with everyone you think could benefit by it.  And good luck.

Related posts:

1. Dr. Oz on Preventing Breast Cancer (Watch Video)
2. The Seriously Serious Problems of Obesity, Cancer and Obesity
3. Guidelines Push Back Age for Cervical Cancer Tests

About half of Americans of the fairer sex get it, and most get it repeatedly.  It’s unhealthy, a nuisance and can be avoided.  Here’s how Dr. Oz suggests you can fight back…

THIS IS a quick post that addresses what some of my woman friends claim is a common ailment among their gender, which for some is so repetitive that it’s made them chronic antibiotic users.  Not a good thing.  Use them too much, and they no longer work, not to mention the disruption to gut and colon health.

I thought to write about this after hearing one female friend complain that “it’s happening again”, the day before I watched a Dr. Oz snippet on the subject.

I’m referring to UTI or Urinary Tract Infection which plagues 50% of women in the USA.  That makes it a big problem, but it doesn’t have to be.

Simply put, a UTI happens when bacteria attaches itself to the bladder lining. The bacteria is often some form of Escherichia coli that migrates from the anus.  If you haven’t noticed, it doesn’t have to travel far.

On a female, it’s a quick trip for bacteria to go from the anus to the urethra (Guys: it’s from where a female urinates), and then up the urethra to the bladder. Once there, the bacteria sticks to the bladder wall and causes all sorts of discomforting symptoms, such as:

• A strong, persistent urge to urinate.
• A burning sensation when urinating.
• Passing frequent, small amounts of urine.
• Urine that appears cloudy.
• Urine that appears bright pink or cola colored — a sign of blood in the urine.
• Strong-smelling urine.
• Pelvic pain, in women.
• Rectal pain, in men.

Unless you’re UTIs are chronic, usually one antibiotic pill saves the day, otherwise more may be necessary.

(Should you use any type of antibiotic, concurrently take probiotics to keep the right balance of beneficial bacteria in your gut and colon for digestive health.  The antiobiotics destroy all the bacteria it can, including what you need.  Probiotics will replenish the good stuff. They’re in most health food stores, or you can eat a lot of yogurt and fermented foods.)

Tips for preventing and treating urinary tract infections include:

1. Single dose of Trimethoprim-Sulfamethoxadzole antibiotic.
2. Cranberry juice.  it coats the lining of the bladder which prevents the bacteria from sticking to the bladder wall.  (Don’t drink it if on blood thinners.)
3. Wipe from front to back.
4. Pee after sex.
5. Eat horseradish – its oil has anti-bacterial properties.
6. Drink peppermint tea – the Menthols in peppermint tea are toxic to bacteria.
7. Take 1,000 milligrams of vitamin C which will acidify urine which is problematic for bacteria.

There’s more information about UTI at the famed Mayo Clinic here.

If you have a solution to UTI that’s not mentioned here, please let us know in the Comments section below.

Related posts:

1. Urinary and Kidney Health… Don’t Get Stoned!
2. Dr. Oz on Preventing Breast Cancer (Watch Video)
3. Four Solutions to Antibiotic-resistant Super Bed Bugs

You pay a painful price for a poor diet should it impact your kidneys by causing kidney stones.

(Watch videos below)

LIKE WITH the liver, the key to kidney health — beyond a good diet (extremely important) and exercise — are supplements that cleanse, restore and maintain.  Toxins need to be flushed out.  Heavy metals need to be flushed out.  Antioxidants need to be introduced to help make the kidneys strong.

There’s no point in cleansing the kidney’s without including the liver, so consider reading this post about liver health and this one on general cleansing.

And here’s a page about “How to Keep Your Kidney’s Healthy” from a fun site devoted to kidneys.

Here are two good supplements that I often use:

Prostate Care This contains the three highly touted ingredients for prostate health in one formula: Saw Palmetto, Pumpkin seed, and Pygeum bark.  With prostate cancer being among the top cancers to effect men, I look at this supplement as some insurance.

UPDATE:  This has been discontinued (Metal Detox too).  Will find a replacement.

Methionine Detox Complex I alternate this one with Heavy Metal Detox and use them only when cleansing.

And this one is well regarded for women:

Cranberry Concentrate For women who want to promote proper urinary tract function, Cranberry Concentrate extract offers a convenient alternative to high calorie cranberry juice, this product offers a dried fruit 8:1 concentrate, providing you with eight times the amount of cranberry than in a normal serving of juice, without any of the sugar and calories. Cranberries contain a natural anti-adherence factor that limits helps the body the amount of unhealthy bacteria collecting on urinary tract tissue to help maintain optimal urinary tract health.

Go here for a list of Product Categories.

Wondering if you’re kidney’s are healthy? Many people aren’t aware if they’re at risk.  The next two videos discuss risk factors, treatment and prevention:

Click here to view the embedded video.

Click here to view the embedded video.

If you take antibiotics for anything, make sure you supplement with probiotics, such as Jarro-Dophilus EPS by Jarrow Formulas.

Diet and genetics’ influence on creating kidney stones, which is becoming prevalent in children, is presented here:

Supplement Disclaimer

Just as with the descriptive statements made at the various company sites that manufacture and/or sell the supplement products presented in this blog, none, or nearly none, of the potential benefits stated here have been evaluated by the FDA. Likewise none, or nearly none, of the products here can be represented to diagnose, treat, cure or prevent any disease. Before engaging a supplement program, it always makes sense to get the advice of your health practitioner.

Related posts:

1. 7 Tips for Preventing (and Combating) Urinary Tract Infections, says Oz
2. The Liver: It Needs Cleaning (Watch Video)
3. Detoxifying Your Way to Nirvana